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Updated: Jun 13, 2026

Assessment of Boron Doped Diamond Electrode Quality and Application to In Situ Modification of Local pH by Water Electrolysis
Published on: January 6, 2016
Square-wave voltammetric determination of propranolol and atenolol in pharmaceuticals using a boron-doped diamond
Elen Romão Sartori1, Roberta Antigo Medeiros, Romeu C Rocha-Filho
1Departamento de Química, Universidade Federal de São Carlos, São Carlos, SP, Brazil.
Abstract:
The independent determination of two beta-blocker agents, namely propranolol (PROP) and atenolol (ATN), in pharmaceutical formulations using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode is described. These electroanalytical determinations of propranolol or atenolol were carried out in 0.1molL(-1) H(2)SO(4) or 0.5molL(-1) NaNO(3) (pH 1.0, adjusted with concentrated HNO(3)), respectively. Excellent linear calibration curves, ranging from 0.20 to 9.0micromolL(-1) for PROP and from 2.0 to 41micromolL(-1) for ATN, with detection limits of 0.18 and 0.93micromolL(-1), respectively, were obtained. The obtained recoveries range from 93.9% to 105.0%, for PROP, and from 92.5% to 106.0%, for ATN. The proposed method was successfully applied in the determination of both beta-blockers in several pharmaceutical formulations (tablets), with results in close agreement at a 95% confidence level with those obtained using official spectrophotometric methods.
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