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Occurrence of antibodies to protease-treated histones in a patient with vasculitis
A Caturla1, J A Colome, A Bustos
1Department of Immunology, Hospital Universitario San Carlos, Madrid, Spain.
Abstract:
We describe the presence of IgG antibodies reacting with histones previously treated with proteases in a patient with vasculitis. The patient's serum did not react with nontreated histones and when several enzymes were tested separately, only alpha-chymotrypsin reproduced the effect. Reactivity was directed against histone fraction H2B and no other autoantibody was found in the patient's serum. This could represent an autoantigen-driven response, histones hydrolyzed in vivo with proteases being the immunogenic stimulus. Diagnostic and pathogenic implications derived from the existence of such autoantibodies are discussed.
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