Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unlocking an All-Anisotropic-Component Integrated Paradigm Toward Practical Solid-State Zinc Metal Pouch Cells.

Angewandte Chemie (International ed. in English)·2026
Same author

Fluorinated Zr-MOF supported Cu(I) for synergistic four-component CO<sub>2</sub> reactions.

Chemical communications (Cambridge, England)·2026
Same author

LINC01012 Drives Hepatitis B-Related Hepatocellular Carcinoma Progression Through HNRNPL-Mediated Stabilization of Serine/Threonine-Protein Kinase-S.

Journal of medical virology·2026
Same author

Toxic effects induced by individual and combined exposures of glyphosate and POEA in honey bees.

Journal of hazardous materials·2026
Same author

Gelatinous drop-like amyloid in FOXC2 distichiasis syndrome: a case report.

BMC ophthalmology·2026
Same author

Social Determinants of Health and Outcomes in Hospitalized Patients with Heart Failure With Preserved Ejection Fraction.

Journal of cardiac failure·2026
Same journal

Gut microbiota alterations in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis.

Journal of Alzheimer's disease : JAD·2026
Same journal

Stage-dependent relationship between sleep duration and cortical tau deposition in cognitively impaired individuals: A cross-sectional study.

Journal of Alzheimer's disease : JAD·2026
Same journal

Multilayer brain connectivity and long-term cognitive changes in individuals at risk for Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026
Same journal

The creation and verification of a detection model for mild cognitive impairment by employing eye-tracking and gait metrics.

Journal of Alzheimer's disease : JAD·2026
Same journal

Compartment-specific analysis reveals disrupted astrocytic calcium transients in anesthetized Alzheimer's disease mice.

Journal of Alzheimer's disease : JAD·2026
Same journal

<i>APOE</i> ε4-specific associations between agitation, cerebrospinal fluid biomarkers, and cognitive decline in cognitively impaired patients.

Journal of Alzheimer's disease : JAD·2026
See all related articles

Related Experiment Video

Updated: Jun 13, 2026

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model
06:07

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model

Published on: June 23, 2023

Mitochondrial dysfunction in Parkinson's disease.

Jianhui Zhu1, Charleen T Chu

  • 1Department of Pathology (Division of Neuropathology), University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Journal of Alzheimer'S Disease : JAD
|May 6, 2010
PubMed
Summary
This summary is machine-generated.

Mitochondrial dysregulation is central to Parkinson's disease (PD) pathogenesis. Impaired mitochondrial quality and clearance mechanisms, particularly mitophagy, are key factors in PD development and progression.

More Related Videos

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

Related Experiment Videos

Last Updated: Jun 13, 2026

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model
06:07

Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model

Published on: June 23, 2023

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

Area of Science:

  • Neuroscience
  • Cell Biology
  • Genetics

Background:

  • Mitochondrial dysregulation is implicated in Parkinson's disease (PD) and other neurodegenerative disorders.
  • Impaired mitochondrial quality arises from increased damage and reduced repair or clearance of damaged mitochondria.
  • Deficits in mitochondrial respiratory chain function, oxidative stress, morphology, and calcium handling are observed in PD models.

Purpose of the Study:

  • To review the central role of mitochondrial dysregulation in Parkinson's disease pathogenesis.
  • To highlight common deficits observed across various PD model systems.
  • To discuss the emerging role of macroautophagy and mitophagy in PD.

Main Methods:

  • Review of human tissue studies, neurotoxin models, and genetic models of PD.
  • Analysis of molecular mechanisms involving key Parkinsonian genes (e.g., alpha-synuclein, PINK1, Parkin, DJ-1).
  • Examination of mitochondrial functions including respiratory chain, oxidative stress, morphology, and calcium handling.

Main Results:

  • Consistent evidence links mitochondrial dysregulation to PD.
  • Common deficits in mitochondrial function are observed across diverse PD models.
  • Alterations in macroautophagy and mitophagy are increasingly implicated in PD pathogenesis.

Conclusions:

  • Mitochondrial health is crucial for preventing PD.
  • Understanding mitoprotective functions and compensatory mechanisms offers therapeutic strategies.
  • Further research into mitophagy regulation is needed to resolve outstanding questions.