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Autoimmune pancreatitis: a report from India
Mohd T Noor1, Anupam Lal, Rakesh Kochhar
1Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
JOP : Journal of the Pancreas
|May 6, 2010
Summary
Autoimmune pancreatitis (AIP) is rare in India. Early diagnosis and steroid treatment are crucial for managing this immune-mediated pancreatic condition, improving patient outcomes.
Area of Science:
- Gastroenterology
- Immunology
- Oncology
Background:
- Autoimmune pancreatitis (AIP) is an immune-mediated pancreatic disease characterized by inflammation, lymphocytic infiltration, and fibrosis.
- While accounting for 4.6-6% of chronic pancreatitis cases globally, few cases have been reported from India.
Purpose of the Study:
- To evaluate cases of autoimmune pancreatitis diagnosed between July 2006 and June 2009.
- To assess the diagnostic challenges and treatment responses in Indian patients with AIP.
Main Methods:
- Retrospective analysis of clinical records of patients diagnosed with autoimmune pancreatitis.
- Evaluation included initial diagnosis, treatment, imaging, cytology, serology, other organ involvement, and treatment response.
- Study conducted at a tertiary care center in northern India.
Main Results:
- Five cases of autoimmune pancreatitis (AIP) were identified (4 males, 1 female; age 48-60 years).
- Diagnosis delay ranged from 3 months to 7 years; common symptoms included obstructive jaundice, abdominal pain, and weight loss.
- Initial misdiagnoses included pancreatic mass, biliary stricture, and primary sclerosing cholangitis, often requiring biliary stenting before AIP diagnosis was considered.
Conclusions:
- This study highlights the need for a high index of suspicion for diagnosing autoimmune pancreatitis in India.
- Autoimmune pancreatitis demonstrates a dramatic positive response to steroid therapy, emphasizing the importance of timely and accurate diagnosis.
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