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Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

Chronic Pancreatitis II: Pathophysiology

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
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Cells and Secretions of the Pancreas

Cells and Secretions of the Pancreas

The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
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Pancreas

Pancreas

The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
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Related Experiment Video

Updated: Jun 13, 2026

Application of Mid-Pancreatectomy with End-to-End Anastomosis in Pancreatic Benign Tumors

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Mesopancreas: myth or reality?

Manish K Agrawal¹, Dilip Singh Thakur, Uday Somashekar

¹Department of Surgery, Government NSCB Medical College, Jabalpur, MP, India.

JOP : Journal of the Pancreas

|May 6, 2010

Summary

The proposed

Area of Science:

Anatomical studies
Surgical anatomy

Background:

A recent hypothesis proposed the 'mesopancreas' as a distinct anatomical structure.
This structure was defined as a firm, well-vascularized entity posterior to the pancreatic head and mesenteric vessels.

Purpose of the Study:

To anatomically verify and define the existence of the mesopancreas.
This involved examining resection specimens from fresh cadavers.

Main Methods:

A postmortem anatomical-pathological study was conducted.
Twenty fresh adult cadavers were utilized, with specimens including the pancreas, duodenum, and major vessels removed en-bloc.
Gross and histopathological examinations were performed to identify a fibrous sheath around the retropancreatic tissue.

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Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation

Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation

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Published on: August 7, 2015

Main Results:

Retropancreatic tissue contained loose areolar tissue, adipose tissue, nerves, lymphatic vessels, and capillaries.
This tissue extended from the pancreas to the aorto-caval groove.
No distinct fibrous sheath or fascia, characteristic of a mesopancreas, was identified.

Conclusions:

The study found no anatomical evidence to support the existence of a 'mesopancreas'.
The retropancreatic tissues examined lacked the defined fibrous structure hypothesized in previous studies.