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The impact of CCL3L1 copy number in an HIV-1-infected white population
Erika Y Lee1, Feng Y Yue, Richard B Jones
1Department of Immunology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Abstract:
We examined the effect of CCL3L1 gene copy number on disease progression in a North American white cohort of HIV-1-infected individuals. Although CCL3L1 copy number is enriched in uninfected Caucasians, in HIV-1-infected individuals CCL3L1 copy number did not correlate either with long-term nonprogression or with CD4 cell count or viral load in chronic progressors. These findings underscore the heterogeneity of factors involved with long-term nonprogression when comparing cohorts of varying ethnic backgrounds.
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