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Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: Jun 13, 2026

Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids

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Published on: June 5, 2015

Evolution of induced pluripotent stem cell technology.

Hongyan Zhou¹, Sheng Ding

¹Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.

Current Opinion in Hematology

|May 6, 2010

Summary

Induced pluripotent stem cells (iPSCs) offer a simpler, ethical alternative to embryonic stem cells for patient-specific therapies. Ongoing research focuses on understanding iPSC mechanisms, safety, and improving reprogramming methods for regenerative medicine.

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Last Updated: Jun 13, 2026

Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids

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Published on: June 5, 2015

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Generation of Induced Pluripotent Stem Cells by Reprogramming Human Fibroblasts with the Stemgent Human TF Lentivirus Set

Generation of Induced Pluripotent Stem Cells by Reprogramming Human Fibroblasts with the Stemgent Human TF Lentivirus Set

Published on: December 8, 2009

Area of Science:

Stem Cell Biology
Regenerative Medicine
Epigenetics

Background:

Induced pluripotent stem cell (iPSC) technology utilizes defined transcription factors to reprogram somatic cells into pluripotent cells.
This method offers technical simplicity and generates patient-specific cells, mitigating ethical concerns associated with embryonic stem cells.

Purpose of the Study:

To review recent advancements in the understanding of induced pluripotent stem cells (iPSCs).
To discuss improved methodologies for generating iPSCs.

Main Methods:

Review of current literature on iPSC generation and characterization.
Analysis of recent progress in reprogramming techniques, including those with minimal or no exogenous genetic modification.

Main Results:

iPSCs are functionally similar to embryonic stem cells, though some differences require further characterization.
Rapid advancements have been made in developing iPSC generation methods with reduced genetic manipulation.

Conclusions:

iPSC technology presents significant opportunities for biomedical research and regenerative medicine.
Further research is needed on iPSC safety, reprogramming mechanisms, and directed reprogramming processes.
Future progress hinges on mechanistic studies, iPSC-based disease modeling, and the discovery of small molecules to modulate reprogramming.