Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Humoral Immune Responses

Humoral Immune Responses

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

What is the Immune System?

What is the Immune System?

Blood Typing

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...

The ABO Blood Group

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bialellic Mutations in Tetratricopeptide Repeat Domain 7A (TTC7A) Cause Common Variable Immunodeficiency-Like Phenotype with Enteropathy.

Journal of clinical immunology·2017

Same author

Downregulation of myeloma-induced ICOS-L and regulatory T cell generation by lenalidomide and dexamethasone therapy.

Cellular immunology·2015

Same author

Do defective B cells contribute to reduced Treg cells and autoimmunity in patients with Common Variable Immunodeficiency?

Immunology letters·2012

Same author

Effect of combined dexamethasone/lenalidomide therapy on NK cell-receptor levels in myeloma patients.

Blood·2011

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

Primary antibody deficiency syndromes.

Philip M Wood¹

¹Department of Clinical Immunology, St. James's University Hospital, Leeds, UK. Philip.wood@leedsth.nhs.uk

Current Opinion in Hematology

|May 6, 2010

Summary

Primary antibody deficiency syndromes, like common variable immunodeficiency disorders (CVIDs), are increasingly understood. Recent findings clarify genetic factors, regulatory T cells, and innate immunity, improving diagnosis and prognosis for these rare disorders.

More Related Videos

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

Published on: February 16, 2017

Related Experiment Videos

Last Updated: Jun 13, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

Published on: February 16, 2017

Area of Science:

Immunology
Genetics
Clinical Medicine

Background:

Primary antibody deficiency syndromes are rare, complex disorders, with common variable immunodeficiency disorders (CVIDs) being most prevalent.
Increased patient survival with immunoglobulin therapy necessitates a focus on CVIDs complications.
Advances in understanding immune regulation and B-cell signaling have accelerated CVIDs research.

Purpose of the Study:

To review recent advancements in understanding the pathogenesis, diagnosis, and management of primary antibody deficiency syndromes.
To highlight progress in CVIDs research, particularly concerning genetic factors and immune dysregulation.
To discuss the implications of new findings for patient prognosis and diagnostic precision.

Main Methods:

Analysis of updated prevalence and incidence data for primary antibody deficiencies.
Exploration of genetic variations, specifically in TACI, within CVID populations.
Investigation into the role of regulatory T cells and innate immune system dysfunction in CVID pathogenesis.

Main Results:

Updated epidemiological data reveal trends in diagnosis and management of primary antibody deficiencies.
Genetic variations in TACI are further implicated in CVID pathogenesis.
The critical role of regulatory T cells in CVID-associated immune dysregulation is increasingly evident.
Emerging evidence points to innate immune system dysfunction in CVID pathogenesis.
Novel clinical presentations of these disorders are continually being identified.

Conclusions:

Recent findings offer potential for more precise prognostic and diagnostic information for individual patients with CVIDs.
Distinguishing primary etiological factors from secondary disease-modifying phenomena remains a key challenge in CVID research.