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The effects of fluoride on bone.

H E Gruber¹, D J Baylink

¹Skeletal Dysplasia Morphology Lab, Cedars-Sinai Medical Center, Los Angeles, California 90048.

Clinical Orthopaedics and Related Research

|June 1, 1991

Summary

Fluoride treatment for osteoporosis shows mixed results. Recent data challenges its effectiveness and raises concerns about fracture risk, making it not generally recommended for postmenopausal osteoporosis currently.

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Area of Science:

Endocrinology
Geriatrics
Pharmacology

Background:

Osteoporosis is a significant metabolic bone disease in the elderly.
Fluoride has historically been a treatment option for osteoporosis.
Monitoring patient response to fluoride therapy is crucial.

Purpose of the Study:

To review current fluoride monitoring techniques for osteoporosis.
To examine new findings on fluoride's mechanism of action, toxicity, and clinical efficacy.
To assess the role of dosage, administration, and side effects in fluoride treatment protocols.

Main Methods:

Literature review of recent clinical trial data.
Analysis of studies on fluoride's interaction with osteoblasts.
Evaluation of toxicity and carcinogenesis data related to fluoride.

Main Results:

New insights into fluoride's interaction with osteoblasts via growth factors.
Concerns regarding fluoride's toxicity and carcinogenic potential.
Recent clinical data question the efficacy of fluoride for postmenopausal osteoporosis, particularly regarding fracture incidence.

Conclusions:

Fluoride's effectiveness in treating postmenopausal osteoporosis is challenged by recent studies.
The implications for fracture incidence necessitate caution.
Fluoride is not currently recommended for general use in osteoporosis treatment.

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