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Updated: Jun 13, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Molecular recognition in copper trafficking
Lucia Banci1, Ivano Bertini, Kathleen S McGreevy
1Department of Chemistry, University of Florence, Fiorentino, Italy. banci@cerm.unifi.it
Abstract:
From the basic export of unwanted metal ions in simple organisms to the complex orchestration of metal handling and usage in higher eukaryotes, cellular systems are based on a variety of molecular mechanisms that constrain the right metal to bind to the right protein partner at the right time when needed. A failure to overcome the challenges inherent in this task can lead to pathological states that compromise the life of the cell. This is indeed the case with copper, a metal ion that is essential but which can however also create toxic effects when its intracellular concentration and distribution are not properly controlled. Research in this field increasingly indicates that a subtle interplay between metal coordination chemistry and protein-protein interactions finely tunes molecular recognition.
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