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Updated: Jun 13, 2026

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
Published on: October 3, 2025
The importance of open-source integrative genomics to drug discovery
Elissa J Chesler1, Erich J Baker
1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. elissa.chesler@jax.org
Abstract:
Researchers investigating many areas of disease recognize the value of integrating large-scale genomic experiments across species and experimental methods. Analysis methods have been developed to make use of the breadth and depth of data from new technologies. Current paradigms of data storage, sharing and analysis are not yet ideal for these purposes. Open-access and analysis-enabled repositories are critical to progress, as they put the global integration of genomic data within reach of individual expert investigators. Current analytic approaches use the full scale and scope of data, but require data sharing, interoperability and community recognition of the value of shared information.
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