Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

American Trypanosomiasis01:22

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Diversity of Protists I01:15

Diversity of Protists I

Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Symbiosis00:58

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatocyte-specific Cas9-mediated editing of G6pc and Slc37a4 elicits comparable biochemical and regulatory responses between glycogen storage disease (GSD) type Ia and Ib mice.

Molecular metabolism·2026
Same author

Microvillus inclusion disease-associated MYO5B deficiency impairs endosome-to-mitochondrion iron transfer.

Gastroenterology report·2026
Same author

Untargeted Proteomics Profiling of Liver and Plasma in Fed and Fasted Liver-Specific Glycogen Storage Disease Type Ia (GSD Ia) Mice: Toward Potential Protein Biomarkers.

Journal of inherited metabolic disease·2026
Same author

Metabolic thermodynamics: pertinent reference state and energy potentials.

The FEBS journal·2026
Same author

Loss of Early Growth Response Protein 1 in the Liver Leads to Hepatic Lipid Accumulation Driven by an Imbalance Between Fatty Acid β-Oxidation and Oxidative Phosphorylation.

Gastro hep advances·2026
Same author

Proteomics profiling of serum and liver in GSD Ia and Ib patients: insights into complication mechanisms and circulation biomarkers.

Journal of translational medicine·2026
Same journal

Parasites of a keystone megaherbivore: insights into trematode life cycles and biological invasions in the Greater Kruger ecosystem.

Parasitology·2026
Same journal

Integrative description of <i>Udonella umgibeli</i> n. sp. (Monopisthocotylea: Udonellidae) as an epibiont of <i>Caligus tetrodontis</i> Barnard, 1948, off the coast of South Africa.

Parasitology·2026
Same journal

Clarifying the taxonomic status of <i>Syphatineria</i> (<i>Africanoxys</i>) <i>cepapi</i> Hugot, 1981 (Nematoda: Oxyuridae) in <i>Paraxerus cepapi</i> Smith, 1836 with new insights into its morphology, ecology and genetics.

Parasitology·2026
Same journal

Major human brain parasites. A narrative review of clinical, diagnostic, and therapeutic strategies.

Parasitology·2026
Same journal

Parasite transmission risk at the urban human-dog-macaque Interface.

Parasitology·2026
Same journal

Morphological characterisation of <i>Echinococcus equinus</i> from lions (<i>Panthera leo</i>) in the greater Kruger National Park, South Africa.

Parasitology·2026
See all related articles

Related Experiment Video

Updated: Jun 13, 2026

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model
08:20

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model

Published on: October 27, 2023

The silicon trypanosome.

Barbara M Bakker1, R Luise Krauth-Siegel, Christine Clayton

  • 1Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. b.m.bakker@med.umcg.nl

Parasitology
|May 7, 2010
PubMed
Summary
This summary is machine-generated.

African trypanosomes are valuable unicellular models for systems biology research. Developing a

More Related Videos

Detection of Trypanosoma brucei Variant Surface Glycoprotein Switching by Magnetic Activated Cell Sorting and Flow Cytometry
09:45

Detection of Trypanosoma brucei Variant Surface Glycoprotein Switching by Magnetic Activated Cell Sorting and Flow Cytometry

Published on: October 19, 2016

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)
14:26

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)

Published on: April 6, 2019

Related Experiment Videos

Last Updated: Jun 13, 2026

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model
08:20

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model

Published on: October 27, 2023

Detection of Trypanosoma brucei Variant Surface Glycoprotein Switching by Magnetic Activated Cell Sorting and Flow Cytometry
09:45

Detection of Trypanosoma brucei Variant Surface Glycoprotein Switching by Magnetic Activated Cell Sorting and Flow Cytometry

Published on: October 19, 2016

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)
14:26

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)

Published on: April 6, 2019

Area of Science:

  • Systems biology
  • Parasitology
  • Genomics

Background:

  • African trypanosomes are unicellular organisms with unique advantages for systems biology.
  • They possess relative simplicity, available genomics techniques, and a history of quantitative research.

Purpose of the Study:

  • To describe the achievements in trypanosome systems biology.
  • To outline steps toward creating a 'Silicon Trypanosome' – a comprehensive mathematical model of trypanosome physiology.

Main Methods:

  • Utilizing genomics techniques, including sequencing, microarrays, and RNA-interference.
  • Employing high-accuracy metabolomics and existing kinetic data for glycolytic enzymes.
  • Developing experiment-based dynamic models of biochemical pathways.

Main Results:

  • Established reproducible cultivation methods for distinct trypanosome life-cycle stages.
  • Developed a dynamic model for a key biochemical pathway (glycolysis) based on extensive kinetic data.
  • Highlighted the potential of systems biology approaches in trypanosome research.

Conclusions:

  • The 'Silicon Trypanosome' model is a necessary step towards a comprehensive understanding of trypanosome physiology.
  • Quantitative modeling will be crucial for identifying new anti-parasite drug targets.
  • African trypanosomes represent a powerful model system for advancing biological research and drug discovery.