Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parenteral Anesthetics: Overview

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...

Prevention of Further Absorption of Poison

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neostigmine Versus Sugammadex for Reversal of Neuromuscular Blockade in Elderly Patients: A Blinded Randomised Study.

Acta anaesthesiologica Scandinavica·2025

Same author

Intubating conditions during rapid sequence induction with either rocuronium or suxamethonium in elderly patients. A randomised study.

Acta anaesthesiologica Scandinavica·2025

Same author

Preoperative anaesthesia triage with a patient-centred system-A prospective clinical study.

Acta anaesthesiologica Scandinavica·2020

Same author

[Acute compartment syndrome following a total knee arthroplasty].

Ugeskrift for laeger·2012

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model

Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model

Published on: February 10, 2023

[Accidental intra-arterial propofol injection].

Maj Kjaergaard¹, Marie Louise Rovsing

¹Glostrup Hospital, Operations- og Anaestesiologisk Afdeling Y, Denmark. majkjaergaard@hotmail.com

Ugeskrift for Laeger

|May 7, 2010

Summary

Accidental intra-arterial injection of propofol caused temporary hand swelling and redness. Symptoms resolved spontaneously, highlighting the need to identify and prevent accidental arterial cannulation during propofol administration.

Area of Science:

Anesthesiology
Pharmacology

Background:

Propofol is a common anesthetic agent.
Accidental intra-arterial injection is a rare but serious complication.

Observation:

A 37-year-old woman received accidental intra-arterial propofol during gynecological surgery.
The patient experienced immediate hand pain, hyperemia, and swelling.

Findings:

Symptoms were transient, resolving spontaneously within 15 minutes.
No specific treatment was required, and the patient had no functional deficit.

Implications:

Clinicians must be vigilant to prevent accidental arterial cannulation.
Difficulty during infusion or sudden pain during propofol administration warrants exclusion of intra-arterial injection.

More Related Videos

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Published on: October 26, 2018

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

Related Experiment Videos

Last Updated: Jun 13, 2026

Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model

Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model

Published on: February 10, 2023

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Published on: October 26, 2018

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021