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Updated: Jun 13, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Role of genetic pattern on bone mineral density in thalassemic patients
Agostino Gaudio1, Nancy Morabito, Anastasia Xourafa
1Department of Internal Medicine, University of Catania, Ospedale Vittorio Emanuele, Via Plebiscito 628, 95124, Catania, Italy.
Objectives:
To evaluate the role of genetic background in osteoporosis/osteopenia development in beta-Thalassemia Major patients.
Design And Methods:
The influence of VDR (FokI, BsmI) as well as COLIA1 (Sp1) gene polymorphisms on BMD was investigated in 40 patients.
Results:
Although the examined gene polymorphisms did not significantly affect BMD variations in our population, BsmI was found to display beneficial effects on patient response to alendronate therapy.
Conclusion:
Genetic factors retain a potential role for improvement of osteoporosis management in thalassemic patients.
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