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Related Experiment Videos

[Kimura disease with minimally proliferative glomerulonephritis].

D Uthgenannt1, J Steinhoff, G Baretton

  • 1Klinik für Innere Medizin, Medizinischen Universität Lübeck.

Deutsche Medizinische Wochenschrift (1946)
|June 14, 1991
PubMed
Summary

Kimura's disease, a rare condition, was unusually associated with minimally proliferative glomerulonephritis in a patient presenting with lymph node swellings and nephrotic syndrome. Treatment with prednisolone effectively managed both conditions.

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Area of Science:

  • Nephrology
  • Immunology
  • Dermatology

Background:

  • Kimura's disease is a rare chronic condition characterized by benign lymphoid hyperplasia with prominent eosinophilic inflammation.
  • It typically presents with painless subcutaneous nodules, often in the head and neck region, and may be associated with elevated IgE levels.

Observation:

  • A 45-year-old male presented with submandibular and retroauricular swellings, polydipsia, polyuria, and nephrotic syndrome.
  • Laboratory findings included elevated IgE and IgA, eosinophilia (14%), and significant proteinuria (14 g/24h).
  • Renal biopsy showed minimal change glomerulonephritis, while tumor excision confirmed Kimura's disease.

Findings:

  • The patient experienced regression of clinical and biochemical findings with 20 mg daily prednisolone.

Related Experiment Videos

  • Recurrence of nephrotic syndrome occurred upon dose reduction, necessitating re-escalation of prednisolone.
  • Symptom-free status was maintained for six months on 20 mg daily prednisolone.

    • Implications:

    • This case highlights an unusual association between Kimura's disease and minimally proliferative glomerulonephritis.
    • It underscores the potential for systemic manifestations of Kimura's disease beyond typical cutaneous and lymphoid involvement.
    • Corticosteroid therapy appears effective in managing the glomerulonephritis associated with Kimura's disease.