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Updated: Jun 13, 2026
07:48
Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
Published on: May 24, 2016
Prognosis for neonates with enterovirus myocarditis
Matthias W Freund1, Gitta Kleinveld, Tannette G Krediet
1Department of Neonatology, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands.
Summary
Neonatal enterovirus (EV) myocarditis is a severe condition with high mortality and long-term cardiac damage. Most survivors experience chronic heart failure, left ventricular aneurysms, and mitral regurgitation, requiring ongoing medical care.
Area of Science:
- Pediatrics
- Cardiology
- Infectious Diseases
Background:
- Neonatal enterovirus (EV) myocarditis is a rare but serious condition.
- Early diagnosis and management are crucial for improving outcomes.
Purpose of the Study:
- To evaluate the severity and long-term cardiac prognosis of enterovirus (EV) myocarditis in neonates.
- To analyze clinical presentation, diagnostic findings, and outcomes.
Main Methods:
- Retrospective analysis of seven neonatal EV myocarditis cases.
- Inclusion of 28 previously reported cases for a combined analysis.
- Assessment of clinical data, echocardiography, ECG, and PCR for Coxsackie virus B.
Main Results:
- 31% mortality rate observed in the combined cohort (35 cases).
- 66% of survivors developed severe cardiac damage, including left ventricular dysfunction, mitral regurgitation, and aneurysm formation.
- Only 23% of infants achieved full recovery.
Conclusions:
- Neonatal EV myocarditis carries a significant risk of mortality and severe chronic cardiac sequelae.
- Long-term complications include heart failure, ventricular aneurysms, and mitral regurgitation, necessitating chronic medical management.
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