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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Nodular amelanotic melanoma.

Rashmi Nalamwar¹, Vidya Kharkar, Sunanda Mahajan

¹Department of Dermatology, Seth G S Medical College and KEM Hospital, Parel, Mumbai, India.

Indian Journal of Dermatology, Venereology and Leprology

|May 7, 2010

Summary

This summary is machine-generated.

A rare case of amelanotic melanoma, a type of skin cancer lacking pigment, was diagnosed in a 65-year-old male. The advanced stage (TNM stage III) involved thigh metastasis and inguinal lymph node involvement, requiring oncological surgery.

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Amelanotic melanoma (AM) presents diagnostic challenges due to its lack of typical pigmentation.
Early detection and accurate staging are crucial for effective management of melanoma.

Observation:

A 65-year-old male presented with a six-month history of a nodular mass on his right thigh.
Physical examination revealed right inguinal lymphadenopathy.
Biopsy confirmed atypical melanocytes, positive for S100 and HMB-45, indicating amelanotic melanoma.

Findings:

Histopathological analysis revealed diffuse nests of atypical melanocytes extending to the reticular dermis (Clarke level IV).
Magnetic Resonance Imaging (MRI) demonstrated a fungating soft tissue mass and metastatic inguinal adenopathy.
Fine Needle Aspiration Cytology (FNAC) confirmed metastatic melanoma in the inguinal lymph nodes, classifying the case as TNM stage III.

Implications:

This case highlights the importance of considering amelanotic melanoma in the differential diagnosis of non-pigmented skin lesions.
Accurate staging using imaging and cytology is essential for treatment planning.
Referral to oncosurgery is indicated for advanced-stage amelanotic melanoma.