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Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in

Tatjana Damnjanovic1, Radomir Milicevic, Tanja Novkovic

  • 1School of Medicine daggerSchool of Dentistry, Institute of Human Genetics, Belgrade, Serbia.

Journal of Pediatric Hematology/Oncology
|May 7, 2010
PubMed
Abstract

Insights

The MTHFR 677C>T gene variant may reduce the risk of childhood acute lymphoblastic leukemia. This finding relates to folate metabolism and DNA synthesis, crucial for cancer development.

Area of Science:

  • Genetics
  • Oncology
  • Biochemistry

Background:

  • Methylenetetrahydrofolate reductase (MTHFR) is vital for folate and methionine metabolism.
  • MTHFR gene polymorphisms are linked to various cancer susceptibilities.
  • Acute lymphoblastic leukemia (ALL) is a significant childhood cancer.

Purpose of the Study:

  • To examine the association between MTHFR gene polymorphisms (677C>T and 1298A>C) and the risk of acute lymphoblastic leukemia in children.

Main Methods:

  • Genotyping of MTHFR polymorphisms (677C>T and 1298A>C) was performed.
  • Genotype and allele frequencies were compared between 78 pediatric ALL patients and control groups.

Main Results:

  • Significant differences in MTHFR 677 genotype and allele frequencies were observed between ALL patients and controls.
  • Individuals with CT/TT genotypes at MTHFR 677 showed a statistically significant reduced risk of ALL (OR=0.53; 0.30).
  • The MTHFR 1298A>C polymorphism did not demonstrate a significant difference between patients and controls.

Conclusions:

  • The MTHFR 677C>T polymorphism is associated with a reduced risk of acute lymphoblastic leukemia in children.
  • The MTHFR 1298A>C polymorphism is not significantly associated with ALL risk in this cohort.
  • These findings highlight the role of MTHFR in childhood leukemia etiology.

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