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Obesity, hypertension and insulin resistance in childhood--a pilot study

Dalibor Pastucha1, Viktor Talafa, Jana Malincikova

  • 1Department of Rehabilitation and Sports Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic. dpastucha@email.cz

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
|May 7, 2010
PubMed

Insights

Obese and hypertensive children show altered insulin sensitivity markers. The QUICKI index offers a more reliable measure for assessing insulin resistance in pediatric populations for epidemiological studies.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Nutritional Science

Background:

  • Obesity and arterial hypertension are significant risk factors for insulin resistance, diabetes, and other health issues.
  • Rising childhood obesity and sedentary lifestyles contribute to the increasing prevalence of metabolic syndrome globally.
  • Early onset of obesity and hypertension in children can precede hyperinsulinemia, highlighting the need for early detection.

Purpose of the Study:

  • To compare homeostatic indices HOMA and QUICKI in obese, healthy, and hypertensive children.
  • To identify convenient markers for assessing insulin sensitivity in clinical pediatric practice.
  • To evaluate the utility of HOMA and QUICKI for mapping childhood insulin resistance.

Main Methods:

  • Study included 49 obese children, 42 healthy children, and 37 hypertensive children.
  • Average levels of HOMA (Homeostatic Model Assessment) and QUICKI (Quantitative Insulin Sensitivity Check Index) were calculated for each group.
  • Statistical analysis was performed to compare the indices between the groups.

Main Results:

  • Obese children had a higher average HOMA (4.58) compared to healthy (1.8) and hypertensive (2.75) children.
  • Obese children had a lower average QUICKI (0.22) compared to healthy (0.29) and hypertensive (0.28) children.
  • QUICKI demonstrated lower variability and a narrower confidence interval than HOMA.

Conclusions:

  • HOMA and QUICKI indices can be used to assess insulin sensitivity in pediatric practice.
  • QUICKI is a more reliable marker due to its lower variability, making it suitable for clinical use.
  • Both indices are valuable for epidemiological studies, particularly for identifying the scope of insulin resistance in children.
Abstract

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