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Differentiation of Human Pluripotent Stem Cells Into Pancreatic Beta-Cell Precursors in a 2D Culture System
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Recent advances in pancreas development: from embryonic pathways to programming renewable sources of beta cells

Victoria E Prince1, Mary D Kinkel

  • 1Department of Organismal Biology & Anatomy, The University of Chicago 1027 E 57th Street, Chicago, IL 60637 USA.

F1000 Biology Reports
|May 7, 2010
PubMed
Abstract

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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...