Related Experiment Videos
Translocation t(8;16)(p11;p13) in neonatal acute monocytic leukaemia
1Department of Paediatrics, University of Tsukuba, Ibaraki-ken, Japan.
Abstract:
A recent report demonstrated that t(8;16) (p11;p13) may be linked to acute monocytic leukaemia (AMoL) of differentiated subtype (M5b) with active haemophagocytosis by leukaemic cells. Only two cases of neonatal AMoL with t(8;16) (p11;p13) have been reported; M5b with haemophogocytosis and M5a. We report a case of neonatal AMoL (M5b) with t(8;16)(p11;p13), but haemophagocytosis by the leukaemic cells was not detected.
Insights
This study reports a rare case of neonatal acute monocytic leukaemia (AMoL) with a specific genetic translocation, t(8;16). Unlike previous cases, this infant with M5b subtype did not exhibit haemophagocytosis by leukaemic cells.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Acute monocytic leukaemia (AMoL) is a subtype of acute myeloid leukaemia.
- The translocation t(8;16)(p11;p13) has been associated with AMoL, particularly with haemophagocytosis.
- Neonatal AMoL is rare, with only two prior cases involving t(8;16) reported.
Observation:
- A case of neonatal AMoL, specifically subtype M5b, was identified.
- The infant presented with the characteristic translocation t(8;16)(p11;p13).
- Crucially, haemophagocytosis by the leukaemic cells was not observed in this patient.
Findings:
- The presence of t(8;16)(p11;p13) in neonatal AMoL (M5b) is confirmed.
- This case expands the spectrum of clinical presentations associated with this genetic abnormality.
- The absence of leukaemic cell haemophagocytosis in this instance challenges previous associations.
Implications:
- Further research is needed to understand the role of t(8;16) in AMoL pathogenesis.
- This finding may refine diagnostic criteria and prognostic indicators for neonatal leukaemias.
- Understanding variations in presentation, like the absence of haemophagocytosis, is critical for tailored treatment strategies.