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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
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Reference change values of blood analytes from physically active subjects.

Lázaro Alessandro S Nunes1, René Brenzikofer, Denise Vaz de Macedo

  • 1Departamento de Bioquímica, Laboratório de Bioquímica do Exercício-LABEX, Instituto de Biologia, Universidade de Campinas-Unicamp, Cidade Universitária Zeferino Vaz, s/n, Barão Geraldo, Campinas, SP, CEP 13083-970, Brazil.

European Journal of Applied Physiology
|May 7, 2010
PubMed
Summary

Reference change values (RCV) for blood tests change with aerobic training. Understanding these shifts in RCV for athletes improves monitoring of training-induced alterations and performance-enhancing substance use.

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Area of Science:

  • Exercise Physiology
  • Clinical Biochemistry
  • Hematology

Background:

  • Blood constituent analysis detects physiological and pathological states.
  • Longitudinal monitoring requires understanding reference change value (RCV) or critical difference.
  • RCV accounts for analytical and biological variations in consecutive measurements.

Purpose of the Study:

  • To calculate biological variation, analytical variation, and RCV for biochemical and hematological parameters.
  • To assess changes in these parameters in male subjects undergoing regular aerobic training for 4 months.

Main Methods:

  • Monthly blood sampling from 56 male subjects (17-19 years old) over 4 months.
  • Analysis of creatine kinase, aspartate aminotransferase, cholesterol, triglycerides, uric acid, C-reactive protein, alpha-1-acid glycoprotein, creatinine, and urea.
  • Hemogram analysis using KX-21 N SYSMEX equipment.

Main Results:

  • RCV values for leukocytes and most biochemical analytes were elevated in trained subjects compared to sedentary individuals.
  • RCV values for red blood cell count were slightly lower in physically active subjects.
  • Training alters the expected biological variation and analytical variation for key blood parameters.

Conclusions:

  • Knowledge of RCV in physically active individuals enhances the detection of training-induced hematological and biochemical alterations.
  • This improved sensitivity/specificity aids in monitoring training effects and detecting the use of substances like recombinant erythropoietin.
  • RCV is crucial for accurate longitudinal monitoring in athletes.