Related Experiment Video
Updated: Feb 27, 2026
10:27
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
8.0K
Molecular pathology and patient care
1Department of Pathology and Immunology at Washington University School of Medicine, St. Louis, USA. pfeifer@path.wustl.edu
Missouri Medicine
|May 8, 2010
Summary
Genetic testing is revolutionizing surgical pathology beyond diagnosis. It now aids in predicting disease prognosis, treatment response, and identifying predispositions, enhancing patient care.
Area of Science:
- Pathology
- Genetics
- Molecular Biology
Background:
- Histopathologic examination is the traditional method for analyzing tissue specimens.
- Laboratory testing for the genetic basis of disease is increasingly vital in pathology.
Purpose of the Study:
- To highlight the expanding role of molecular laboratory testing in surgical pathology.
- To discuss genetic techniques beyond their diagnostic applications.
Main Methods:
- Analysis of tissue specimens using genetic techniques.
- Integration of molecular testing with traditional histopathology.
Main Results:
- Genetic testing is crucial for predicting prognosis.
- Molecular techniques identify likelihood of response to treatments.
- Genetic testing monitors for minimal residual disease and disease predispositions.
Conclusions:
- Molecular laboratory testing significantly enhances surgical pathology.
- Genetic techniques offer predictive and prognostic value in disease management.
- The role of genetic testing extends beyond diagnosis to personalized medicine.
More Related Videos
11:15Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
25.1K
13:24Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
Published on: April 11, 2016
12.3K
Related Concept Videos
01:20Applications of Molecular Taxonomy
630
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
630
01:29Modern Molecular Taxonomy
775
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
775
02:50Combination Therapies and Personalized Medicine
6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K
02:07Tumor Progression
7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
01:13Patient-centered Care
3.2K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.2K
01:21Cancer Survival Analysis
797
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
797