Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Airway Obstruction due to Retropharyngeal Hematoma Following Cervical Spine Fracture Resulting in Cardiac Arrest.

Journal of emergencies, trauma, and shock·2026
Same author

Impact of antiemetic use on stroke cases from the Japanese Society Aeromedical Service Registration System.

Journal of rural medicine : JRM·2026
Same author

Effect of head injury on blood transfusion requirements in severe trauma: a post-hoc analysis of the RESTRIC trial.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
Same author

Implementation tendencies and expert perspectives on physician-performed prehospital endotracheal intubation in Japan: Findings from the first round of a Delphi survey.

PloS one·2026
Same author

Outcomes of Patients with Aortic Diseases Treated by Antiemetic Drug, Who Were Transported by a Physician-staffed Helicopter in Japan.

Journal of emergencies, trauma, and shock·2026
Same author

Outcomes of patients with unstable circulation transported by a physician-staffed helicopter using the keyword method in Japan.

Journal of rural medicine : JRM·2025
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Related Experiment Video

Updated: Jun 13, 2026

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

[Ischemic heart disease].

Hiromichi Ohsaka1, Takashi Kiyanagi, Hiroyuki Daida

  • 1Department of Cardiovascular Medicine, Juntendo University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 8, 2010
PubMed
Summary
This summary is machine-generated.

Diabetes mellitus is linked to severe cardiovascular disease, including complex coronary artery stenoses. Early non-invasive cardiovascular evaluation and treatment are crucial for diabetic patients to prevent macrovascular complications.

More Related Videos

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
10:21

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test

Published on: September 22, 2023

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
08:01

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System

Published on: June 11, 2020

Related Experiment Videos

Last Updated: Jun 13, 2026

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
10:21

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test

Published on: September 22, 2023

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
08:01

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System

Published on: June 11, 2020

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetology

Context:

  • Insulin resistance, impaired glucose tolerance, and diabetes mellitus are strongly associated with cardiovascular disease.
  • Diabetic patients often present with multi-vessel coronary artery disease characterized by complex, calcified stenoses.
  • Hyperglycemia, insulin resistance, and diabetic nephropathy contribute to advanced atherosclerosis and cardiovascular pathology in diabetes.

Purpose:

  • To highlight the intricate relationship between diabetes mellitus and cardiovascular disease.
  • To emphasize the pathological mechanisms linking diabetes to complex coronary artery conditions.
  • To underscore the importance of early cardiovascular assessment and intervention in diabetic individuals.

Summary:

  • Diabetes mellitus is closely correlated with cardiovascular disease, often manifesting as multi-vessel coronary artery disease with complex, calcified stenoses.
  • Pathological features of diabetes, including hyperglycemia, insulin resistance, and nephropathy, exacerbate atherosclerosis and cardiovascular complications.
  • Diabetic neuropathy can lead to silent ischemia, masking advanced atherosclerosis, thus necessitating proactive cardiovascular evaluation.

Impact:

  • Early non-invasive cardiovascular evaluation, such as CT coronary angiography, is vital for diabetic patients.
  • Prompt and appropriate treatment strategies are essential to mitigate the risk of macrovascular disease development.
  • This approach aims to improve long-term outcomes and prevent severe cardiovascular events in individuals with diabetes.