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Re-examination of Rattus norvegicus as an animal model for Aeromonas-associated enteritis in man
R L Haberberger1, W P Yonushonis, R L Daise
1Department of Research Sciences, U.S. Naval Medical Research Unit No. Three, Cairo, Egypt.
Abstract:
We have developed an oral feeding model for Aeromonas hydrophila enteritis using Rattus norvegicus with clindamycin pretreatment. All animals in the clindamycin group developed a self-limited, loose stool by day four of feeding. Intestinal examination revealed evidence of enteritis. Moreover, antibiotic usage may be a predisposing risk factor to infection.