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Pseudomeningocele induced transient loss of consciousness in Marfan syndrome

E Kohler1, D Prentice

  • 1Royal Perth Hospital, Perth, Western Australia, Australia. edith_kohler@hotmail.com

Internal Medicine Journal
|May 8, 2010
PubMed

Insights

Marfan syndrome can cause severe dural ectasia, leading to meningoceles and pseudomeningoceles. A case report highlights a woman with Marfan syndrome experiencing transient loss of consciousness due to intracranial pressure changes from a pseudomeningocele.

Area of Science:

  • Neurology
  • Genetics
  • Radiology

Background:

  • Marfan syndrome is a genetic disorder affecting connective tissue.
  • Dural ectasia, particularly meningoceles and pseudomeningoceles, is a severe manifestation.
  • These conditions can present with varied neurological symptoms.

Observation:

  • A case report details a 31-year-old woman with Marfan syndrome.
  • She presented with recurrent transient loss of consciousness.
  • This was suspected to be linked to intracranial pressure fluctuations from a pseudomeningocele.

Findings:

  • Anterior and posterior meningoceles represent the most severe form of dural ectasia in Marfan syndrome.
  • Meningoceles and pseudomeningoceles can cause a spectrum of symptoms, from asymptomatic to severe neurological deficits.
  • The case highlights a potential, albeit rare, presentation of pseudomeningocele-induced intracranial pressure changes causing syncope.

Implications:

  • This case broadens the understanding of potential neurological complications in Marfan syndrome.
  • It emphasizes the importance of considering dural ectasia in patients with unexplained neurological symptoms.
  • Further investigation into the relationship between pseudomeningoceles and intracranial pressure dynamics is warranted.

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