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Published on: June 6, 2025
Acute promyelocytic leukemia during pregnancy
Laura Ganzitti1, Giorgio Fachechi, Lorenza Driul
1Clinic of Obstetrics and Gynaecology, University Hospital of Udine, Udine, Italy. ganzittilaura@live.it
Fertility and Sterility
|May 8, 2010
Summary
This case report details the successful management of acute promyelocytic leukemia (APL) in a pregnant patient. Modern chemotherapy and close monitoring ensured a positive outcome for both mother and baby.
Area of Science:
- Hematology
- Obstetrics
- Oncology
Background:
- Acute promyelocytic leukemia (APL) is a rare but aggressive subtype of leukemia.
- Pregnancy with APL presents unique challenges for maternal and fetal management.
Observation:
- A 32-year-old pregnant woman at 25 weeks gestation was diagnosed with APL.
- A multidisciplinary approach was employed to manage the maternal malignancy and ensure fetal well-being.
Findings:
- The patient received chemotherapy, and the baby was born with no neurological deficits.
- Both mother and baby demonstrated good health outcomes, with APL in remission.
Implications:
- This case highlights the feasibility of treating APL during pregnancy with modern chemotherapy.
- Close collaboration between hematologists and obstetricians is crucial for successful outcomes in pregnant APL patients.
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