Testosterone and coronary artery disease in men

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Carolyn M Webb1, Peter Collins

  • 1Cardiovascular Sciences, National Heart & Lung Institute, Imperial College London, London, UK. c.webb@imperial.ac.uk

Maturitas
|May 8, 2010
PubMed

Insights

Low testosterone levels are linked to worse coronary artery disease (CAD) in men. This review explores testosterone

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Vascular Biology

Background:

  • Coronary artery disease (CAD) is a major cause of mortality.
  • Lower endogenous testosterone levels correlate with increased CAD extent and severity in men.
  • Testosterone influences CAD risk factors and vascular functions.

Purpose of the Study:

  • To review the impact of endogenous testosterone and testosterone therapy on CAD.
  • To examine testosterone's effects on CAD risk factors, vascular health, and atheroma.
  • To discuss the potential therapeutic role of testosterone in men with CAD.

Main Methods:

  • Literature review of studies on testosterone and cardiovascular health.
  • Analysis of research on testosterone's effects on vascular tone, vasoreactivity, and blood flow.
  • Examination of evidence regarding testosterone's influence on atheroma development and progression.

Main Results:

  • Testosterone affects multiple CAD risk factors.
  • Testosterone influences vascular tone, vasoreactivity, and blood flow.
  • Evidence suggests a role for testosterone in atheroma progression.

Conclusions:

  • Testosterone plays a role in CAD pathogenesis.
  • Testosterone therapy may have potential benefits for men with CAD.
  • Further research is warranted on testosterone's therapeutic applications in cardiovascular disease.

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