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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Survival Analysis01:21

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Related Experiment Video

Updated: Jun 13, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

Breakthrough pain in oncology: a longitudinal study.

Sebastiano Mercadante1, Vittoria Zagonel, Enrico Breda

  • 1Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy. terapiadeldolore@lamaddalenanet.it

Journal of Pain and Symptom Management
|May 8, 2010
PubMed
Summary

Breakthrough pain (BP) in cancer patients remains prevalent over time, though its intensity decreases. Longitudinal assessment is crucial for understanding this complex pain phenomenon.

Related Experiment Videos

Last Updated: Jun 13, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

Area of Science:

  • Oncology
  • Pain Management
  • Clinical Research

Background:

  • Previous breakthrough pain (BP) studies used varied methods, yielding inconsistent prevalence rates.
  • Cross-sectional designs limited understanding of BP's trajectory and analgesic treatment relationship.

Purpose of the Study:

  • To longitudinally assess breakthrough pain (BP) in cancer patients within oncology units.
  • To evaluate BP characteristics and analgesic effectiveness over time.

Main Methods:

  • A consecutive sample of oncology patients was followed over six months (T0, T3, T6).
  • Data collected included background pain, BP intensity, duration, episodes, onset with movement, spontaneous relief, activity limitation, and analgesic effectiveness.

Main Results:

  • 302 patients completed the study; continuous pain prevalence was stable (33-39%).
  • Pain intensity significantly decreased over six months (P=0.004-0.027).
  • Breakthrough pain (BP) prevalence decreased from 87.1% at T0 to 73.2% at T6 (P=0.016); pain on movement limited activity.

Conclusions:

  • Breakthrough pain (BP) remains a significant issue for cancer patients, decreasing in prevalence but persisting.
  • Longitudinal assessment is vital for understanding BP, influenced by disease stage, patient factors, and treatment.