Related Experiment Video
Updated: Jun 13, 2026
Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
Positional relationship between recurrent intracerebral hemorrhage/lacunar infarction and previously detected
1Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Science, Hiroshima, Japan. sueda0323@hotmail.com
Background And Purpose:
Although MBs, ICH, and LI are secondary to cerebral microangiopathy, it remains unclear whether the location of subsequent ICH/LI corresponds to the previous location of MBs. We performed this study to clarify the positional relationship between recurrent ICH/LI and previously detected MBs.
Materials And Methods:
We evaluated patients with recurrent ICH/LI who had MBs, as shown on prior T2*-weighted MR imaging. We assessed retrospectively whether the location of recurrent ICH/LI corresponded to that of the prior MB. Patients with ICH were divided into the deep ICH group and the lobar ICH group, and the positional relationship between hematoma and previously detected MBs was evaluated.
Results:
A total of 55 patients, including 34 with recurrent ICH and 21 with recurrent LI were evaluated. Although the location of the LI corresponded to prior MBs in only 1 patient (4.8%), the location of ICH corresponded to prior locations of MBs in 21 patients (61.8%) (OR, 32.3; 95% CI, 3.86-270.3; P < .001). Among the patients with ICH, the correspondence ratio was higher in the deep ICH group (19 of 24 patients, 79.2%) than in the lobar ICH group (2 of 10 patients, 20%) (OR, 15.2; 95% CI, 2.42-95.3; P < .002).
Conclusions:
The close positional association between recurrent ICH and prior MBs suggests that MBs represent hemorrhage-prone microangiopathy. In addition, different correspondence ratios between the deep ICH group and the lobar ICH group may be attributable to their different pathogenesis.
Insights
Recurrent cerebral microbleeds (MBs) strongly correlate with the location of subsequent intracerebral hemorrhage (ICH), particularly in deep brain regions. This suggests MBs indicate areas prone to bleeding in cerebral microangiopathy.
Area of Science:
- Neurology
- Radiology
- Cerebrovascular Diseases
Background:
- Cerebral microangiopathy can lead to microbleeds (MBs), intracerebral hemorrhage (ICH), and lobar hemorrhage (LI).
- The relationship between the location of prior MBs and subsequent ICH/LI is not well understood.
Purpose of the Study:
- To investigate the positional relationship between recurrent ICH/LI and previously detected MBs.
- To clarify if MBs predict the location of subsequent hemorrhages.
Main Methods:
- Retrospective analysis of 55 patients with recurrent ICH/LI and prior MBs on T2*-weighted MRI.
- Assessed correspondence between locations of recurrent ICH/LI and prior MBs.
- Categorized ICH into deep and lobar groups to evaluate positional relationships.
Main Results:
- ICH location corresponded to prior MBs in 61.8% of patients, while LI location corresponded in only 4.8%.
- The correspondence ratio for ICH was significantly higher in the deep ICH group (79.2%) compared to the lobar ICH group (20%).
- A strong association was found between prior MBs and recurrent ICH (OR, 32.3; P < .001).
Conclusions:
- MBs are indicative of hemorrhage-prone microangiopathy.
- The close positional association between recurrent ICH and prior MBs highlights their link.
- Differences in correspondence ratios between deep and lobar ICH suggest distinct underlying pathogenetic mechanisms.
Related Concept Videos
01:17Hemorrhagic Stroke l: Introduction
01:29Hemorrhagic Stroke ll: Pathophysiology