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Updated: Jun 13, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
Polynomial algebra of discrete models in systems biology
Alan Veliz-Cuba1, Abdul Salam Jarrah, Reinhard Laubenbacher
1Virginia Bioinformatics Institute, Department of Mathematics, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA. alanavc@vt.edu
Motivation:
An increasing number of discrete mathematical models are being published in Systems Biology, ranging from Boolean network models to logical models and Petri nets. They are used to model a variety of biochemical networks, such as metabolic networks, gene regulatory networks and signal transduction networks. There is increasing evidence that such models can capture key dynamic features of biological networks and can be used successfully for hypothesis generation.
Results:
This article provides a unified framework that can aid the mathematical analysis of Boolean network models, logical models and Petri nets. They can be represented as polynomial dynamical systems, which allows the use of a variety of mathematical tools from computer algebra for their analysis. Algorithms are presented for the translation into polynomial dynamical systems. Examples are given of how polynomial algebra can be used for the model analysis.
Contact:
alanavc@vt.edu
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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