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Updated: Jun 13, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
Published on: February 17, 2011
Ligand binding prediction for BRCA1, a key molecule in the pathogenesis of breast cancer
1Wiwanitkit House, Bangkhae, Bangkok 10160, Thailand.
Background:
Cell adhesion plays a pivotal role in diverse biological processes that occur in oncogenesis. BRCA1 was the first breast cancer susceptibility gene to be successfully identified and cloned. The role of BRCA1 as a predictive marker of chemotherapy response in breast cancer is proposed. Ligand binding is an important factor in the success of chemoprevention.
Materials And Methods:
In this work, the author performed a ligand-binding prediction for BRCA1 using a new bioinformatics tool.
Results:
According to this study, 10 strong possible ligands were identified.
Conclusion:
These sites can be useful for further drug development studies.
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