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Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However, frequent irregular...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...

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Related Experiment Video

Updated: Jun 13, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Circadian clock and vascular disease.

Norihiko Takeda1, Koji Maemura

  • 1Division of Biology, University of California, San Diego, CA, USA.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|May 8, 2010
PubMed
Summary

The body's internal biological clock influences cardiovascular health, with disruptions linked to diseases like hypertension. Restoring clock balance may offer new ways to treat cardiovascular disorders.

Area of Science:

  • Cardiovascular physiology
  • Chronobiology
  • Molecular genetics

Background:

  • Cardiovascular functions exhibit diurnal oscillations, with circadian variations impacting events like heart attacks.
  • Mammalian clock genes are expressed throughout the body, forming central and peripheral biological clocks.
  • Peripheral clocks regulate organ-specific functions via clock-controlled genes (CCGs).

Purpose of the Study:

  • To investigate the role of the vascular peripheral clock in cardiovascular disorders.
  • To understand how circadian rhythm disruptions contribute to cardiovascular diseases.
  • To explore chronotherapeutic strategies for cardiovascular disease prevention and treatment.

Main Methods:

  • Utilized genetically engineered mice with disrupted circadian rhythms.

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Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

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Related Experiment Videos

Last Updated: Jun 13, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

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07:42

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Published on: September 17, 2016

  • Investigated the impact of circadian disruption on endothelial function, hypertension, and hemostasis.
  • Examined the consequences of central and peripheral clock desynchronization.

    • Main Results:

    • Disrupted circadian rhythms in mice demonstrated a role for the internal clock in endothelial dysfunction, hypertension, and hemostasis.
    • Loss of synchronization between central and peripheral clocks contributes to cardiovascular disease pathogenesis.
    • Restoring clock homeostasis showed potential in preventing disease progression.

    Conclusions:

    • The peripheral clock in vasculature plays a critical role in cardiovascular health.
    • Circadian rhythm disruption and desynchronization are key factors in cardiovascular disease development.
    • Identifying CCGs and developing phase-manipulating tools can lead to novel chronotherapies for cardiovascular disorders.