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Published on: August 31, 2018
Anti-inflammatory eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex
Bo-Wei Chen1, Chih-Hua Chao, Jui-Hsin Su
1Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Abstract:
Three novel eunicellin-based diterpenoids, namely klysimplexin sulfoxides A-C (1-3), were isolated from the cultured soft coral Klyxum simplex. Their structures were elucidated by spectroscopic methods, particularly 1D and 2D-NMR experiments. Compounds 1-3 significantly inhibited the accumulation of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells. Compound 3 also showed marked activity in inhibiting the expression of COX-2 protein in the same cells.
