Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation02:24

Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation

Introduction
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Catalysis02:50

Catalysis

The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
Catalysis01:27

Catalysis

Catalysis influences the rate of chemical reactions by providing an alternative reaction pathway with lower activation energy. A catalyst speeds up a reaction, but it is not consumed during the process. The fundamental principle of catalysis is the ability of a catalyst to alter the reaction mechanism, often introducing a more efficient pathway than the uncatalyzed process.In a catalyzed reaction, the catalyst participates directly in the reaction mechanism. It interacts with reactants to form...
Heterogeneous Catalysis01:22

Heterogeneous Catalysis

Heterogeneous catalysis involves a catalyst in a different phase from the reactants. It is a process where the catalyst and the reactants are in distinct phases, typically solid and gas or liquid.Most heterogeneous catalysts are metals, metal oxides, or acids. The list includes transition metals like iron (Fe), cobalt (Co), nickel (Ni), palladium (Pd), platinum (Pt), chromium (Cr), manganese (Mn), tungsten (W), silver (Ag), and copper (Cu). These metals possess partially vacant d orbitals that...
Preparation of Alkynes: Alkylation Reaction02:27

Preparation of Alkynes: Alkylation Reaction

Introduction
Alkylation of terminal alkynes with primary alkyl halides in the presence of a strong base like sodium amide is one of the common methods for the synthesis of longer carbon-chain alkynes. For example, treatment of 1-propyne with sodium amide followed by reaction with ethyl bromide yields 2-pentyne.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Asymmetric Catalysis: Recent Advances toward a More Sustainable Synthesis.

ACS central science·2026
Same author

Synthesis of 1,<i>n</i>-Diamines via Selective Catalytic C-H Diamination.

Journal of the American Chemical Society·2025
Same author

Catalyst-Controlled Intermolecular Homobenzylic C(sp<sup>3</sup>)-H Amination for the Synthesis of β-Arylethylamines.

Journal of the American Chemical Society·2024
Same author

EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model.

European journal of medicinal chemistry·2024
Same author

Asymmetric Syntheses of Enantioenriched 2,5-Disubstituted Pyrrolidines.

ACS organic & inorganic Au·2023
Same author

Effect of Air Velocity and Initial Conditioning on the Moisture Buffer Value of Four Different Building Materials.

Materials (Basel, Switzerland)·2023

Related Experiment Video

Updated: Jun 13, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

Published on: June 20, 2014

Catalytic C-H amination: recent progress and future directions.

Florence Collet1, Robert H Dodd, Philippe Dauban

  • 1Institut de Chimie des Substances Naturelles, UPR 2301 CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.

Chemical Communications (Cambridge, England)
|May 8, 2010
PubMed
Summary
This summary is machine-generated.

Catalytic C-H amination has advanced significantly, enabling selective nitrene C-H insertion. New C-H activation/amination methods offer complementary strategies for this important chemical transformation.

More Related Videos

Achieving Moderate Pressures in Sealed Vessels Using Dry Ice As a Solid CO2 Source
06:26

Achieving Moderate Pressures in Sealed Vessels Using Dry Ice As a Solid CO2 Source

Published on: August 17, 2018

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
12:19

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization

Published on: November 29, 2018

Related Experiment Videos

Last Updated: Jun 13, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

Published on: June 20, 2014

Achieving Moderate Pressures in Sealed Vessels Using Dry Ice As a Solid CO2 Source
06:26

Achieving Moderate Pressures in Sealed Vessels Using Dry Ice As a Solid CO2 Source

Published on: August 17, 2018

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
12:19

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization

Published on: November 29, 2018

Area of Science:

  • Organic Chemistry
  • Catalysis
  • Synthetic Methodology

Background:

  • Catalytic C-H amination is a crucial transformation in organic synthesis.
  • Developing selective and efficient methods for C-H amination remains a significant challenge.

Purpose of the Study:

  • To review recent advancements in catalytic C-H amination.
  • To highlight the development of selective nitrene C-H insertion reactions.
  • To discuss emerging C-H activation/amination strategies.

Main Methods:

  • Review of recent literature on catalytic C-H amination.
  • Analysis of novel reagents and catalyst designs for C-H amination.
  • Discussion of intramolecular and intermolecular nitrene C-H insertion reactions.
  • Exploration of C-H activation/amination pathways.

Main Results:

  • Efficient conditions for selective intramolecular and intermolecular nitrene C-H insertion have been developed.
  • Careful design of reagents and catalysts is key to achieving high selectivity.
  • Emergence of C-H activation/amination reactions provides new synthetic opportunities.

Conclusions:

  • Recent progress has significantly advanced catalytic C-H amination.
  • Nitrene C-H insertion is now highly selective due to improved catalyst and reagent design.
  • C-H activation/amination offers complementary approaches to nitrene-based methods.