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Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

Published on: July 3, 2018

Silica-based clicked hybrid glyco materials.

Francisco Santoyo-Gonzalez¹, Fernando Hernandez-Mateo

¹Departamento de Q. Orgánica, Facultad de Ciencias, Instituto de Biotecnología, Universidad de Granada, Granada, 18071, Spain. fsantoyo@ugr.es

Chemical Society Reviews

|May 8, 2010

Summary

Copper-catalyzed click chemistry enables covalent immobilization of carbohydrates onto silica surfaces. This review covers advanced applications of these sophisticated glyco-hybrid materials for constructing novel glyco-structures and devices.

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Last Updated: Jun 13, 2026

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

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Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

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Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry

Published on: October 18, 2019

Area of Science:

Carbohydrate Chemistry
Materials Science
Surface Chemistry

Background:

Click chemistry, particularly copper-catalyzed alkyne-azide cycloadditions (CuAAC), offers efficient bioconjugation strategies.
Silica-based materials are versatile platforms for surface functionalization.
Immobilizing carbohydrates is crucial for developing advanced glyco-materials.

Purpose of the Study:

To critically review the impact of CuAAC on carbohydrate immobilization onto silica.
To highlight the construction of sophisticated glyco-structures and devices.
To describe advanced applications of resulting bioconjugated hybrid materials.

Main Methods:

Copper-catalyzed alkyne-azide cycloaddition (CuAAC) for covalent immobilization.
Surface modification of silica-based materials.
Characterization of resulting glyco-hybrid materials.

Main Results:

Successful covalent attachment of carbohydrates to silica surfaces via click chemistry.
Creation of diverse and complex glyco-structures.
Demonstration of advanced functionalities for novel applications.

Conclusions:

CuAAC is a powerful tool for carbohydrate immobilization on silica.
The developed glyco-hybrid materials exhibit significant potential in various advanced applications.
This review provides a comprehensive overview of the field and future directions.