Related Experiment Video
Updated: Jun 13, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Synthesis, structure and reactivity of azosalophen complexes of vanadium(IV): studies on cytotoxic properties
Poulami Pattanayak1, Jahar Lal Pratihar, Debprasad Patra
1Department of Chemistry, University of Kalyani, Kalyani. 741235, India.
Abstract:
The free ligands, 2-{(o-hydroxyaryl)azo}-1-N-salicylidene phenylamine, H(2)L [where H(2)L = RC(6)H(4)N=NC(6)H(4)N=CH-C(6)H(4)OHR = p-H for H(2)L(1), p-Me for H(2)L(2) and p-Cl for H(2)L(3)], were prepared by the condensation of salicylaldehyde with 2-{(o-hydroxy aryl)azo} aniline. Reaction of H(2)L with VOSO(4) afforded the oxovanadium complex, (L)V(O)(H(2)O). The (L(1))V(O)(H(2)O) complex displays two reversible responses at 0.7 V and -0.65 V vs. SCE in cyclic voltammetry. Catalytic activity of (L(1))V(O)(H(2)O) toward H(2)O(2) induced oxidation of organic thioethers to sulfoxide and sulfones have been examined. The cytotoxicity of (L(1))V(O)(H(2)O) has also been examined on human lung cancer cells.
Related Concept Videos
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Diazonium Group Substitution: –OH and –H
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo, or cyano...
Valence Bond Theory
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...

