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Published on: October 23, 2018
Serum immunoreactive prolyl hydroxylase in liver disease
European Journal of Clinical Investigation
|December 1, 1977
Summary
Serum immunoreactive prolyl hydroxylase (SIRPH) levels were elevated in all liver disease patients, particularly in primary biliary cirrhosis. SIRPH may indicate unknown processes in diseased liver cells.
Area of Science:
- Hepatology
- Biochemistry
- Clinical Chemistry
Background:
- Liver diseases encompass a range of conditions affecting liver function.
- Assessing biomarkers for liver disease diagnosis and prognosis is crucial.
- Serum immunoreactive prolyl hydroxylase (SIRPH) is a potential marker.
Purpose of the Study:
- To measure SIRPH concentrations in patients with various liver diseases.
- To compare SIRPH levels between patient groups and healthy controls.
- To investigate the correlation of SIRPH with liver function tests.
Main Methods:
- Serum samples were collected from patients with chronic active hepatitis, primary biliary cirrhosis, alcoholic/idiopathic cirrhosis, and acute hepatitis.
- SIRPH concentrations were measured using an immunoassay.
- Data were compared to a control group of 23 healthy subjects.
Main Results:
- Elevated SIRPH levels were observed in all patient groups compared to controls.
- The highest SIRPH values were found in patients with primary biliary cirrhosis.
- Approximately two-thirds of primary biliary cirrhosis patients had SIRPH levels exceeding two standard deviations above the control mean.
- No significant correlation was found between SIRPH and standard liver function tests or routine laboratory parameters.
Conclusions:
- SIRPH is elevated in various liver diseases, with the most pronounced increase in primary biliary cirrhosis.
- SIRPH may serve as a sensitive indicator of hepatic cell damage or an unknown pathological process.
- Further research is warranted to elucidate the precise role of SIRPH in liver disease pathogenesis.
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