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Published on: November 9, 2019
Iterative strategies for the synthesis of deoxypropionates
Bjorn ter Horst1, Ben L Feringa, Adriaan J Minnaard
1Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Abstract:
This feature article gives an overview of iterative synthetic methods for the construction of deoxypropionates, an important class of polyketides. The catalytic and non-catalytic methodologies discussed are based on highly stereoselective reactions which can be carried out in an iterative fashion. Non-catalytic methods are described first, followed by state of the art catalytic iterative protocols. The application of the iterative methods in the synthesis of natural products is discussed as well.
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