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Aminoheterocycles as synthons for combinatorial Biginelli reactions

Sergey V Ryabukhin1, Andrey S Plaskon, Sergey Yu Boron

  • 1Enamine Ltd, 23 A. Matrosova St., Kyiv, 01103, Ukraine. Ryabukhin@mail.enamine.net

Molecular Diversity
|May 8, 2010
PubMed
Summary

Chlorotrimethylsilane (TMSCl) efficiently promotes Biginelli reactions for synthesizing dihydropyrimidines. This method allows for the rapid creation of large, diverse chemical libraries with high yields and simple purification.

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