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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...

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Crohns disease: a case report.

Ashindoitiang John Adi1, Geoffrey J Lloyd

  • 1Motayo Hospital Limited 3 Owudunni St., Off Toyin Street, Ikeja, Lagos, Nigeria. ashindoitiang@yahoo.com

Nigerian Quarterly Journal of Hospital Medicine
|May 11, 2010
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel disease (IBD), including Crohn's disease, is increasingly recognized in tropical regions like Nigeria. This case highlights the importance of considering IBD in differential diagnoses, even where it is considered rare.

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Clinical Case Reports

Background:

  • Inflammatory bowel disease (IBD) historically has a high incidence in Western countries.
  • IBD was considered uncommon in Asian populations and rare in Africa.
  • This perception is changing with increasing reports from diverse geographical regions.

Observation:

  • A case of Crohn's disease, a type of IBD, is reported in Nigeria.
  • Crohn's disease is notably rare in tropical climates.
  • This case underscores the need for increased awareness of IBD in such settings.

Findings:

  • The case presentation suggests that IBD may be underdiagnosed in tropical regions.
  • Diagnostic challenges may contribute to the perceived rarity of IBD in Africa.
  • Timely diagnosis of IBD is crucial for effective management.

Implications:

  • This report raises awareness of IBD in Nigeria and similar tropical regions.
  • Healthcare providers should consider IBD in patients presenting with relevant symptoms.
  • Further research is needed to understand the epidemiology and diagnosis of IBD in Africa.