Related Experiment Video
Updated: Jun 13, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Association of ACE I/D polymorphism and recurrent miscarriages in an Italian population with a pre-modern
R M Corbo1, L Ulizzi, L Piombo
1Department of Genetics and Molecular Biology, CNR Institute of Molecular Biology and Pathology, University La Sapienza, Piazzale A. Moro 5, Rome, Italy.
Abstract:
Angiotensin I-converting enzyme (ACE), in addition to its role in the renin angiotensin system, has a physiological function in the fibrinolysis pathway, the accurate control of which is critical for the normal development of pregnancy. Recently, the ACE I/D polymorphism was found to be associated with recurrent spontaneous miscarriages (RM). The present study analysed the relationship between ACE I/D polymorphism and the number of spontaneous miscarriages, the number of pregnancies and the number of children in a sample of 88 Italian women born before 1930, with a pre-modern reproductive behaviour. The ACE DD genotype was more prevalent among women with RM (p = 0.02). However, the women carrying the DD genotype not only had the highest number of miscarriages (p = 0.03), but also the highest number of pregnancies with an eventual complete fertility (children no = 4.4), similar to that of women carrying the other ACE genotypes. In contrast, published data on contemporary women with RM seem to indicate that the DD genotype could now be associated with a reduced reproductive success compared to the other ACE genotypes. It is suggested that this phenomenon may be the effect of the interaction between ACE genotypes and contemporary reproductive behaviours (delay in childbearing, below-replacement fertility).
Related Concept Videos
Non-LTR Retrotransposons
Infertility in Males
Nondisjunction
Infertility in Females
Endometriosis, a condition characterized by abnormal growth of endometrial...
Bias in Epidemiological Studies
Multiple Allele Traits

