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Updated: Jun 13, 2026

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Pregnancy-related fibroid reduction.

Shannon K Laughlin1, Amy H Herring, David A Savitz

  • 1Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA. laughlin.shannon@mayo.edu

Fertility and Sterility
|May 11, 2010
PubMed
Summary

Pregnancy significantly reduces uterine fibroids. Most fibroids identified during early pregnancy were undetectable postpartum, and the majority of those remaining decreased in size.

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Area of Science:

  • Reproductive medicine
  • Gynecology
  • Obstetrics

Background:

  • Uterine fibroids (leiomyomas) are common benign tumors affecting women of reproductive age.
  • Parity (having given birth) is associated with a reduced risk of fibroid development.
  • The direct impact of pregnancy on existing fibroids requires further investigation.

Purpose of the Study:

  • To investigate the direct effects of pregnancy on uterine fibroids.
  • To determine fibroid changes from early pregnancy through the postpartum period.

Main Methods:

  • Prospective observational study involving 171 women with at least one uterine fibroid.
  • Ultrasound examinations were conducted during early pregnancy and again postpartum.
  • Fibroid presence and size were assessed at both time points.

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Main Results:

  • 36% of initial fibroids were not identifiable on postpartum ultrasound.
  • Of the fibroids that remained identifiable, 79% showed a decrease in size.
  • These findings suggest a significant regression of fibroids following pregnancy.

Conclusions:

  • Pregnancy exerts a direct protective effect on uterine fibroids.
  • The observed fibroid reduction supports the hypothesis that pregnancy-related factors contribute to fibroid regression.