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Updated: Jun 13, 2026
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Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
A combined approach to patients with repeated IVF failures
Raoul Orvieto1, Simion Meltcer, Gad Liberty
1Department of Obstetrics and Gynecology, Barzilai Medical Centre, Ashkelon, Israel. raoulo@barzi.health.gov.il
Fertility and Sterility
|May 11, 2010
Summary
For repeated in vitro fertilization (IVF) failures, a combined diagnostic hysteroscopy and endometrial sampling approach before an ultrashort gonadotropin-releasing hormone agonist/antagonist protocol improved patient outcomes. This strategy yielded reasonable implantation and clinical pregnancy rates in subsequent IVF cycles.
Area of Science:
- Reproductive Medicine
- Infertility Treatment
- Gynecologic Surgery
Background:
- Recurrent in vitro fertilization (IVF) failure presents a significant challenge in reproductive medicine.
- Identifying underlying causes of implantation failure is crucial for optimizing IVF success rates.
- Previous IVF attempts often lack comprehensive pre-treatment evaluations for uterine factors.
Purpose of the Study:
- To evaluate the efficacy of a combined diagnostic hysteroscopy and endometrial sampling approach in patients with repeated IVF failures.
- To compare stimulation characteristics and outcomes between a combined diagnostic approach and previous IVF attempts.
- To determine if this combined strategy improves implantation and clinical pregnancy rates after failed IVF cycles.
Main Methods:
- A retrospective analysis of 19 IVF cycles was conducted.
- The study involved a combined approach of diagnostic hysteroscopy and endometrial sampling during oral contraceptive pill treatment.
- This intervention preceded an ultrashort gonadotropin-releasing hormone agonist/antagonist protocol in patients with a history of failed IVF.
- Stimulation characteristics and cycle outcomes were compared to the patients' previous failed IVF attempts.
Main Results:
- Patients undergoing the combined diagnostic and treatment approach demonstrated improved outcomes compared to previous attempts.
- The combined approach resulted in an implantation rate of 25%.
- A clinical pregnancy rate of 42% was achieved in the cycles following the combined intervention.
Conclusions:
- The combination of diagnostic hysteroscopy and endometrial sampling prior to an ultrashort GnRH-agonist/antagonist protocol is an effective strategy for patients experiencing repeated IVF failures.
- This integrated approach can enhance reproductive outcomes, leading to improved implantation and clinical pregnancy rates.
- Further research may explore the specific mechanisms by which this combined strategy mitigates factors contributing to IVF failure.
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