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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Association between serum lipoproteins and abdominal aortic aneurysm
Jonathan Golledge1, Frank van Bockxmeer, Konrad Jamrozik
1Vascular Biology Unit, James Cook University School of Medicine, Townsville, Queensland, Australia. jonathan.golledge@jcu.edu.au
The American Journal of Cardiology
|May 11, 2010
Summary
High-density lipoprotein (HDL) levels are linked to a lower risk of abdominal aortic aneurysm (AAA) in men. Current treatments lowering low-density lipoprotein (LDL) may not prevent AAA development.
Area of Science:
- Cardiovascular Medicine
- Lipid Metabolism
- Atherosclerosis Research
Background:
- Dyslipidemia's role in abdominal aortic aneurysm (AAA) etiology is unclear, partly due to not accounting for lipid-modifying medications.
- Lipid-altering drugs are established for occlusive atherosclerosis but their value in AAA primary prevention is unknown.
Purpose of the Study:
- To investigate the association between serum lipid levels (triglycerides, LDL, HDL) and AAA presence in older men.
- To assess if lipid-modifying therapy influences the relationship between lipids and AAA.
Main Methods:
- A cohort of 3,327 men aged 65-83 years was analyzed.
- Fasting serum lipid levels and AAA presence were measured.
- Multiple logistic regression adjusted for AAA risk factors and lipid-modifying agents.
Main Results:
- Lower high-density lipoprotein (HDL) concentrations were observed in men with AAAs.
- HDL was independently associated with reduced AAA risk in both those on and not on lipid-modifying therapy.
- Low-density lipoprotein (LDL) and triglyceride levels showed no association with AAA presence.
Conclusions:
- HDL appears to be a key lipid predictor for AAA development and a potential therapeutic target.
- Current cardiovascular strategies focusing on lowering LDL may not impact AAA prevention.
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