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Related Experiment Videos

Bloodless testing for microporous membrane oxygenator failure: a preliminary study.

Y Tamari1, A J Tortolani, K J Lee-Sensiba

  • 1Department of Surgery, North Shore University Hospital, Manhasset, New York.

The International Journal of Artificial Organs
|March 1, 1991
PubMed
Summary

Albumin and high outlet pressure accelerate microporous membrane oxygenator (MMO) failure in a bloodless test. The Sarns 16310 model showed failure, unlike Bentley and Medtronic models, suggesting a new compatibility testing method.

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Area of Science:

  • Biomedical Engineering
  • Materials Science

Background:

  • Microporous membrane oxygenators (MMOs) are crucial for respiratory support.
  • Understanding MMO failure mechanisms is vital for long-term device reliability.

Purpose of the Study:

  • To investigate the acceleration of MMO failure using a bloodless solution and high pressure.
  • To determine the role of albumin as a wetting agent and high outlet pressure in plasma leakage.
  • To evaluate the compatibility of different MMO models under accelerated testing conditions.

Main Methods:

  • Three MMO models (Bentley BCM-40, Medtronic Maxima, Sarns 16310) were tested in recirculating circuits.
  • Tests used Lactated Ringer solution with and without albumin (4 g/100 ml) at varying MMO outlet pressures (150, 300, 750 mmHg).
  • Failure was defined by Na+ detection in MMO exhaust gas; blood and gas flow were maintained at 2 L/min.

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Main Results:

  • No MMO failures occurred without albumin.
  • Bentley and Medtronic MMOs showed no failure within 78 hours.
  • Sarns MMO failed at 4.9, 12.1, and 19 hours under high pressure and albumin conditions.
  • Preceding failure, inlet gas pressure increased significantly.

Conclusions:

  • Albumin and high MMO outlet pressure may promote plasma breakthrough in the Sarns 16310 model.
  • These factors may provide a basis for an accelerated bloodless test for MMO compatibility.
  • Further research is needed to validate this accelerated testing method for long-term respiratory support devices.