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Related Concept Videos

Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Evolutionary Processes in Microbes01:26

Evolutionary Processes in Microbes

Microbial evolution occurs rapidly due to short generation times and a variety of genetic processes, including horizontal gene transfer, mutation, recombination, and genetic drift. These mechanisms collectively enable microbes to adapt swiftly to changing environments.Horizontal gene transfer (HGT) allows genes to move between different species and occurs through three main mechanisms: conjugation, transformation, and transduction. Conjugation involves direct cell-to-cell contact for DNA...
Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

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Related Experiment Video

Updated: Jun 13, 2026

Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

Impact of recombination on bacterial evolution.

Xavier Didelot1, Martin C J Maiden

  • 1Department of Statistics, University of Warwick, Coventry, CV4 7AL, UK. x.didelot@warwick.ac.uk

Trends in Microbiology
|May 11, 2010
PubMed
Summary

Homologous recombination drives bacterial evolution. Analyzing genetic sequences reveals varying recombination frequencies and impacts across bacterial genomes, influencing gene flow and species definition.

Area of Science:

  • Microbiology
  • Evolutionary Biology
  • Genetics

Background:

  • Genetic exchange is fundamental to bacterial evolution.
  • Homologous recombination is a key mechanism of genetic exchange in bacteria.
  • Advances in nucleotide sequencing facilitate large-scale comparative genomic studies.

Purpose of the Study:

  • To investigate the frequency and impact of homologous recombination in bacterial genomes.
  • To understand patterns of gene flow within bacterial populations.
  • To assess the variability of recombination across bacterial species and lineages.

Main Methods:

  • Comparative analysis of nucleotide sequences from diverse bacterial genera.
  • Examination of genomic regions to determine recombination frequency.

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Preparation of the Mgm101 Recombination Protein by MBP-based Tagging Strategy
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Preparation of the Mgm101 Recombination Protein by MBP-based Tagging Strategy

Published on: June 25, 2013

Related Experiment Videos

Last Updated: Jun 13, 2026

Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

Preparation of the Mgm101 Recombination Protein by MBP-based Tagging Strategy
11:40

Preparation of the Mgm101 Recombination Protein by MBP-based Tagging Strategy

Published on: June 25, 2013

  • Inference of gene flow patterns based on sequence data.

    • Main Results:

    • Recombination frequency and impact vary significantly across different bacterial species and even within species.
    • Homologous recombination affects various genomic regions differently.
    • Patterns of gene flow are shaped by the extent and nature of recombination.

    Conclusions:

    • Nucleotide sequence data provide crucial insights into bacterial recombination dynamics.
    • The variability in recombination has significant implications for understanding bacterial populations and species.
    • Findings impact fields such as bacterial epidemiology and the bacterial species concept.