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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...

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Functional Imaging of Viral Transcription Factories Using 3D Fluorescence Microscopy
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NF-kappaB signaling modulation by EBV and KSHV.

Deilson Elgui de Oliveira1, Gianna Ballon, Ethel Cesarman

  • 1Department of Pathology, Botucatu School of Medicine, Sao Paulo State University (UNESP), Rubiao Junior, s/n - Botucatu, SP 18618-000, Brazil.

Trends in Microbiology
|May 11, 2010
PubMed
Summary

Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV) subvert the crucial nuclear factor-kappaB (NF-kappaB) pathway. This viral manipulation is key to infection and the development of cancers in humans.

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Last Updated: Jun 13, 2026

Functional Imaging of Viral Transcription Factories Using 3D Fluorescence Microscopy
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Published on: January 18, 2018

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08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

Area of Science:

  • Immunology
  • Virology
  • Oncology

Background:

  • The nuclear factor-kappaB (NF-kappaB) signaling pathway is essential for immune responses.
  • Pathogenic microorganisms, including oncogenic gammaherpesviruses like Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), have evolved mechanisms to manipulate NF-kappaB signaling.
  • EBV and KSHV establish lifelong latent infections in humans.

Purpose of the Study:

  • To review the current understanding of how EBV and KSHV modulate the NF-kappaB signaling pathway.
  • To explore the link between viral modulation of NF-kappaB and the development of human cancers.

Main Methods:

  • Literature review of existing research on EBV, KSHV, NF-kappaB signaling, and carcinogenesis.
  • Analysis of viral strategies targeting NF-kappaB.
  • Correlation of viral-induced NF-kappaB modulation with oncogenesis.

Main Results:

  • EBV and KSHV actively subvert NF-kappaB signaling for their own benefit during infection.
  • The dysregulation of NF-kappaB by these viruses is a significant factor in viral pathogenesis.
  • Alterations in NF-kappaB signaling by EBV and KSHV are implicated in the development of malignant neoplasia.

Conclusions:

  • Understanding NF-kappaB modulation by EBV and KSHV is critical for comprehending viral infections and associated cancers.
  • Targeting viral interference with NF-kappaB pathways may offer therapeutic strategies for EBV- and KSHV-associated malignancies.
  • Further research into the intricate interplay between viral biology and host signaling pathways is warranted for advancing cancer prevention and treatment.