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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
Published on: June 26, 2020
Self-association of cyclic oligonucleotides through G:T:G:T minor groove tetrads
Júlia Viladoms1, Núria Escaja, Enrique Pedroso
1Departament de Química Orgànica, Universitat de Barcelona, Barcelona, Spain.
Abstract:
Minor groove aligned tetrads resulting from the association of Watson-Crick base pairs stabilize a distinct class of four-stranded DNA structures, different from G-quadruplexes or i-motifs. These tetrads can be formed by several arrangements of G-C or A-T base pairs. Here we prove that minor groove tetrads can be also formed by G-T mismatches. In this manuscript we describe the dimeric solution structures of two cyclic oligonucleotides stabilized by intermolecular G-T non-canonical base pairs. In the dimeric structure of d
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