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Transforming growth factor-beta inhibits nephronectin-induced osteoblast differentiation

Ling Fang1, Shireen Kahai, Weining Yang

  • 1Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada.

FEBS Letters
|May 11, 2010
PubMed
Summary

Transforming growth factor beta (TGF-beta) inhibits osteoblast differentiation by down-regulating nephronectin (Npnt) expression. This disruption affects cell morphology and hinders Npnt-mediated differentiation, indicating multiple inhibitory mechanisms.

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